Improvement of antibody responses by HIV envelope DNA and protein co-immunization.

Publication Type:

Journal Article


Vaccine, Volume 32, Issue 4, p.507-13 (2014)


2014, Center-Authored Paper, December 2013, Human Biology Division


Developing HIV envelope (Env) vaccine components that elicit durable and protective antibody responses is an urgent priority, given the results from the RV144 trial. Optimization of both the immunogens and vaccination strategies will be needed to generate potent, durable antibodies. Due to the diversity of HIV, an effective Env-based vaccine will most likely require an extensive coverage of antigenic variants. A vaccine co-delivering Env immunogens as DNA and protein components could provide such coverage. Here, we examine a DNA and protein co-immunization strategy by characterizing the antibody responses and evaluating the relative contribution of each vaccine component.