Impact of PSA screening on the incidence of advanced stage prostate cancer in the United States: a surveillance modeling approach.

Publication Type:

Journal Article


Medical decision making : an international journal of the Society for Medical Decision Making, Volume 28, Issue 3, p.323-31 (2008)


2008, 258, Aged, Aged, 80 and over, Cohort Studies, Computer Simulation, Humans, Male, Mass Screening, Middle Aged, Population Surveillance, Prostate-Specific Antigen, Prostatic Neoplasms, Public Health, United States


and objective. Both the detection and the treatment of prostate cancer have undergone important clinical advances. Simultaneously, both distant stage incidence and disease-specific mortality have fallen in the United States. A recent study suggests that if prostate-specific antigen (PSA) testing explains the decline in distant stage incidence, then it may be largely responsible for the decline in mortality. The objective was to quantify this link between PSA screening and the decline in distant stage incidence.