Impact of HIV infection and Kaposi sarcoma on human herpesvirus-8 mucosal replication and dissemination in Uganda.

Publication Type:

Journal Article


PloS one, Volume 4, Issue 1, p.e4222 (2009)


2009, Adolescent, Adult, Female, Herpesvirus 8, Human, HIV Infections, Humans, Male, Middle Aged, Mucous Membrane, Multivariate Analysis, Polymerase Chain Reaction, Sarcoma, Kaposi, Uganda, Vaccine and Infectious Disease Institute, Virology, Virus Replication


Kaposi sarcoma (KS) is the leading cause of cancer in Uganda and occurs in people with and without HIV. Human herpesvirus-8 (HHV-8) replication is important both in transmission of HHV-8 and progression to KS. We characterized the sites and frequency of HHV-8 detection in Ugandans with and without HIV and KS.