Impact of HIV infection and Kaposi sarcoma on human herpesvirus-8 mucosal replication and dissemination in Uganda.

Publication Type:

Journal Article

Source:

PloS one, Volume 4, Issue 1, p.e4222 (2009)

Keywords:

2009, Adolescent, Adult, Female, Herpesvirus 8, Human, HIV Infections, Humans, Male, Middle Aged, Mucous Membrane, Multivariate Analysis, Polymerase Chain Reaction, Sarcoma, Kaposi, Uganda, Vaccine and Infectious Disease Institute, Virology, Virus Replication

Abstract:

Kaposi sarcoma (KS) is the leading cause of cancer in Uganda and occurs in people with and without HIV. Human herpesvirus-8 (HHV-8) replication is important both in transmission of HHV-8 and progression to KS. We characterized the sites and frequency of HHV-8 detection in Ugandans with and without HIV and KS.