Impact of body-mass index in the outcome of adult patients with acute myeloid leukemia.

Publication Type:

Journal Article

Source:

Haematologica, Volume 97, Issue 9, p.1401-1404 (2012)

Keywords:

2012, Center-Authored Paper, Clinical Research Division, Consortium Authored Paper, Feb 2012, February 2012, Public Health Sciences Division

Abstract:

ABSTRACTBackground. Obesity increases the risk of treatment-related complications and reduces survival in children with acute myeloid leukemia. Little is known about the impact of obesity on the outcome of adult patients with acute myeloid leukemia. Design and Methods. We compared the baseline characteristics and effect on treatment and survival in 1,974 untreated adult acute myeloid leukemia patients undergoing treatment, according to international classification of body mass index. Results. Median BMI was 26.7 (15.5-61) and 63% of patients were overweight/obese. After adjustment for other confounders of age, gender, performance status, karyotype, white blood cell, platelet and peripheral blast counts, obese patients had improved complete remission rates (p-0.0046), lower rates of resistant disease (p-0.038) but similar survival and severe adverse events. Conclusions. In the treatment of adult AML, obesity was associated with increased response rates, no apparent increase in toxicity, and should not be an exclusion for aggressive therapy.