Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.

Publication Type:

Journal Article

Source:

PloS one, Volume 5, Issue 8, p.e11995 (2010)

Keywords:

2010, Abscess, Adolescent, Adult, Antibody Formation, Center-Authored Paper, Female, Freund's Adjuvant, HIV-1, Humans, Immunization, Male, Mannitol, Middle Aged, Oleic Acids, Peptides, T-Lymphocytes, Vaccine and Infectious Disease Division, Vaccines, Subunit, Young Adult

Abstract:

A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in incomplete Freund's adjuvant (IFA).