IL28B genotype effects during early treatment with peginterferon and ribavirin in difficult-to-treat hepatitis C virus infection.

Publication Type:

Journal Article

Authors:

Scott, John; Holte, Sarah; Urban, Thomas; Burgess, Caitlin; Coppel, Erica; Wang, Chia; Corey, Lawrence; McHutchison, John; Goldstein, David

Source:

The Journal of infectious diseases, Volume 204, Issue 3, p.419-25 (2011)

Keywords:

2011, Adult, Center-Authored Paper, Drug Therapy, Combination, Female, Genotype, Hepatitis C, Chronic, Humans, Interferon Alfa-2a, Interleukins, Male, Middle Aged, Models, Theoretical, Polyethylene Glycols, Polymorphism, Single Nucleotide, Public Health Sciences Division, Ribavirin, RNA, Viral, September 2011, Vaccine and Infectious Disease Division

Abstract:

Mathematical models of hepatitis C virus (HCV) during therapy may elucidate mechanisms of action for antiviral therapy. In genome-wide association studies, IL28B gene polymorphisms are highly predictive of therapeutic clearance of HCV.