IL1B genetic variation and plasma C-reactive protein level among young adults: the CARDIA study.

Publication Type:

Journal Article


Atherosclerosis, Volume 202, Issue 2, p.513-20 (2009)


2009, Adolescent, African Continental Ancestry Group, C-Reactive Protein, Center-Authored Paper, European Continental Ancestry Group, Female, Genetic Variation, Haplotypes, Humans, Interleukin-1beta, lipids, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Public Health Sciences Division, Young Adult


Interleukin-1B (IL1B) modulates C-reactive protein (CRP) expression. However, whether IL1B genetic variation is associated with CRP level is unknown. Further, obesity, a state of low-grade inflammation that influences cellular IL-1 functions may modify this association.