Identification and analysis of murine pancreatic islet enhancers.

Publication Type:

Journal Article

Source:

Diabetologia, Volume 56, Issue 3, p.542-52 (2013)

Keywords:

2013, Center-Authored Paper, January 2013, Public Health Sciences Division, Vaccine and Infectious Disease Division

Abstract:

The paucity of information on the epigenetic barriers that are blocking reprogramming protocols, and on what makes a beta cell unique, has hampered efforts to develop novel beta cell sources. Here, we aimed to identify enhancers in pancreatic islets, to understand their developmental ontologies, and to identify enhancers unique to islets to increase our understanding of islet-specific gene expression.