Humoral immunomodulatory effect of influenza vaccine in potential blood donors: implications for transfusion safety.

Publication Type:

Journal Article

Source:

Transfusion medicine (Oxford, England), Volume 21, Issue 6, p.378-84 (2011)

Keywords:

2011, ABO Blood-Group System, Antibodies, Blood Donors, Blood Safety, Blood Transfusion, Center-Authored Paper, Female, HLA Antigens, Humans, Immunity, Humoral, Immunologic Factors, Influenza Vaccines, Male, Oct 11, PREGNANCY, Public Health Sciences Division, Sex Factors

Abstract:

Generalised immune stimulation may follow vaccination causing increased antibody titres of nonvaccine-related antibodies or bystander antibodies, including those to human leukocyte antigens (HLA) and ABO blood group antigens. HLA antibodies may lead to transfusion-related acute lung injury. High-titre ABO antibodies may cause acute haemolytic transfusion reactions after plasma-incompatible platelet transfusion. It is unknown if these antibodies can be stimulated by vaccination in otherwise normal subjects.