Human papillomaviruses: a growing field.

Publication Type:

Journal Article

Source:

Genes & development, Volume 23, Issue 2, p.138-42 (2009)

Keywords:

2009, Culture Techniques, EPITHELIUM, G2 Phase, Human Biology Division, Humans, Papillomaviridae, Papillomavirus Infections, S Phase, Viral Envelope Proteins, Virus Replication

Abstract:

A combination of functional studies on human papillomavirus (HPV) oncoproteins and epidemiological studies on persistence of HPV infection firmly established a role for HPV in the etiology of cervical cancers. Understanding the viral life cycle of HPVs has been more difficult. In this issue of Genes & Development, Wang et al. (pp. 181 - 194) describe an efficient method to propagate infectious HPV in differentiating epithelium, providing clear evidence for temporal separation of viral and cellular replication.