Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time.

Publication Type:

Journal Article

Source:

The Journal of infectious diseases, Volume 207, Issue 8, p.1206-15 (2013)

Keywords:

2013, Cross-Sectional Studies, env Gene Products, Human Immunodeficiency Virus, Female, Genes, Viral, Genitalia, Female, Genotype, GLYCOSYLATION, HIV Infections, HIV-1, Humans, Likelihood Functions, Longitudinal Studies, May 2013, Phylogeny, Public Health Sciences Division, Reproductive Tract Infections, RNA, Viral, Sequence Analysis, RNA, Species Specificity, Time Factors, Virus Replication

Abstract:

Whether unique human immunodeficiency type 1 (HIV) genotypes occur in the genital tract is important for vaccine development and management of drug resistant viruses. Multiple cross-sectional studies suggest HIV is compartmentalized within the female genital tract. We hypothesize that bursts of HIV replication and/or proliferation of infected cells captured in cross-sectional analyses drive compartmentalization but over time genital-specific viral lineages do not form; rather viruses mix between genital tract and blood.