HUGIn: Hi-C Unifying Genomic Interrogator.

Publication Type:

Journal Article

Source:

Bioinformatics (Oxford, England) (2017)

Abstract:

Motivation: High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.

Results: We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell lines. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTLs results and functional genomics data.

Availability: HUGIn is available at http://yunliweb.its.unc.edu/HUGIn .

Contact: yunli@med.unc.edu and hum@ccf.org .

Supplementary information: Supplementary data are available at Bioinformatics online.