HSV suppression reduces seminal HIV-1 levels in HIV-1/HSV-2 co-infected men who have sex with men.

Publication Type:

Journal Article


AIDS (London, England), Volume 23, Issue 4, p.479-83 (2009)


2009, Acyclovir, Adult, Antiviral Agents, CD4 Lymphocyte Count, Cross-Over Studies, Double-Blind Method, Herpes Genitalis, Herpesvirus 2, Human, HIV Infections, HIV-1, Homosexuality, Male, Humans, Male, Middle Aged, RNA, Viral, Semen, Vaccine and Infectious Disease Institute, Valine, Viral Load, Young Adult


Suppressive herpes simplex virus (HSV) therapy can decrease plasma, cervical, and rectal HIV-1 levels in HIV-1/HSV-2 co-infected persons. We evaluated the effect of HSV-2 suppression on seminal HIV-1 levels.