Host genetic polymorphisms associated with innate immune factors and HIV-1.

Publication Type:

Journal Article

Source:

Current opinion in HIV and AIDS, Volume 6, Issue 5, p.427-34 (2011)

Keywords:

2011, Center-Authored Paper, September 2011, Vaccine and Infectious Disease Division

Abstract:

Our understanding of the early events in HIV-1 infection continues to grow, along with the heightened recognition of the important contribution that innate immunity plays in response to HIV-1. Here, we review the epidemiological and functional studies of genetic polymorphisms associated with innate immune factors that are believed to modulate host responses, focusing specifically on recent findings related to Toll-like receptor, cytokine, host restriction and KIR genes and their activities.