Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling.

Publication Type:

Journal Article


AIDS (London, England), Volume 24, Issue 11, p.1778-81 (2010)


2010, Adolescent, Adult, Center-Authored Paper, Contraceptives, Oral, Combined, Contraceptives, Oral, Hormonal, Epidemiologic Methods, Female, HIV Infections, HIV-1, Humans, Medroxyprogesterone Acetate, Vaccine and Infectious Disease Division, Young Adult


Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.