HLA-identical sibling compared with 8/8 matched and mismatched unrelated donor bone marrow transplant for chronic phase chronic myeloid leukemia.

Publication Type:

Journal Article

Source:

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 27, Issue 10, p.1644-52 (2009)

Keywords:

2009, Adolescent, Adult, Aged, Bone Marrow Transplantation, Child, Child, Preschool, Clinical Research Division, Disease-Free Survival, Female, Graft vs Host Disease, Histocompatibility Antigens Class I, Humans, Kaplan-Meier Estimate, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Male, Middle Aged, Siblings, Tissue Donors, Treatment Outcome

Abstract:

Transplantation of hematopoietic stem cells from an unrelated donor (URD) is an option for many patients who do not have an HLA-identical sibling donor (MSD). Current criteria for the selection of URDs include consideration for HLA alleles determined by high resolution typing methods, with preference for allele-matched donors. However, the utility and outcome associated with transplants from URDs compared with those from MSDs remains undefined.