HIV Vaccine Trials Network: activities and achievements of the first decade and beyond.

Publication Type:

Journal Article


Clinical investigation, Volume 2, Issue 3, p.245-254 (2012)


2012, Center-Authored Paper, Clinical Research Division, January 2013, Public Health Sciences Division, Vaccine and Infectious Disease Division


The HIV Vaccine Trials Network (HVTN) is an international collaboration of scientists and educators facilitating the development of HIV/AIDS preventive vaccines. The HVTN conducts all phases of clinical trials, from evaluating experimental vaccines for safety and immunogenicity, to testing vaccine efficacy. Over the past decade, the HVTN has aimed to improve the process of designing, implementing and analyzing vaccine trials. Several major achievements include streamlining protocol development while maintaining input from diverse stakeholders, establishing a laboratory program with standardized assays and systems allowing for reliable immunogenicity assessments across trials, setting statistical standards for the field and actively engaging with site communities. These achievements have allowed the HVTN to conduct over 50 clinical trials and make numerous scientific contributions to the field.