HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis.

Publication Type:

Journal Article

Source:

Lancet, Volume 372, Issue 9653, p.1894-905 (2008)

Keywords:

2008, AIDS Vaccines, Female, HIV Antigens, HIV Infections, HIV-1, Humans, Immunity, Cellular, Male, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, T-Lymphocytes, Vaccine and Infectious Disease Institute

Abstract:

In the Step Study, the MRKAd5 HIV-1 gag/pol/nef vaccine did not reduce plasma viraemia after infection, and HIV-1 incidence was higher in vaccine-treated than in placebo-treated men with pre-existing adenovirus serotype 5 (Ad5) immunity. We assessed vaccine-induced immunity and its potential contributions to infection risk.