HIV-1 Specific IgA Detected in Vaginal Secretions of HIV Uninfected Women Participating in a Microbicide Trial in Southern Africa Are Primarily Directed Toward gp120 and gp140 Specificities.

Publication Type:

Journal Article

Source:

PloS one, Volume 9, Issue 7, p.e101863 (2014)

Keywords:

2014, August 2014, Center-Authored Paper, Clinical Research Division, Human Biology Division, Public Health Sciences Division, Vaccine and Infectious Disease Division

Abstract:

Many participants in microbicide trials remain uninfected despite ongoing exposure to HIV-1. Determining the emergence and nature of mucosal HIV-specific immune responses in such women is important, since these responses may contribute to protection and could provide insight for the rational design of HIV-1 vaccines.