HIV-1 maternal and infant variants show similar sensitivity to broadly neutralizing antibodies, but sensitivity varies by subtype.

Publication Type:

Journal Article

Authors:

Mabuka, Jennifer; Goo, Leslie; Omenda, Maxwel M; Nduati, Ruth; Overbaugh, Julie

Source:

AIDS (London, England), Volume 27, Issue 10, p.1535-44 (2013)

Keywords:

2013, August 2013, Center-Authored Paper, Genomics Core Facility, Human Biology Division, Public Health Sciences Division

Abstract:

To protect against HIV infection, passively transferred and/or vaccine-elicited neutralizing antibodies (NAbs) need to effectively target diverse subtypes that are transmitted globally. These variants are a limited subset of those present during chronic infection and display some unique features. In the case of mother-to-child transmission (MTCT), transmitted variants tend to be resistant to neutralization by maternal autologous NAbs.