HIV-1 infection and antibodies to Plasmodium falciparum in adults.

Publication Type:

Journal Article

Source:

The Journal of infectious diseases (2014)

Keywords:

2014, May 2014, Vaccine and Infectious Disease Division

Abstract:

Background. Co-infection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally acquired immunity.Methods. In 339 adults (64% HIV infected), we measured antibodies to Plasmodium falciparum variant surface antigens (VSA) and antibodies that opsonise infected erythrocytes using parasite lines FCR3, E8B and R29, and antibodies to merozoite antigens, AMA-1 and MSP2. We determined the relationship between malaria antibodies, HIV infection, markers of immune compromise, and risk of incident parasitemia.Results. HIV-infected adults had significantly lower mean levels of opsonising antibody to all parasite lines (P<0.0001), and lower levels of antibody to AMA-1 (P=0.01) and MSP2 (P<0.0001). Levels of IgG to VSA were not affected by HIV status. Opsonising antibody titres against some isolates were positively correlated with CD4 count. There were negative associations between HIV-1 viral load and opsonising antibodies to FCR3 (P=0.04), and levels of IgG to AMA-1 (P≤0.03) and MSP2-3D7 (P=0.05). Lower opsonising antibody levels on enrolment were seen in those who became parasitemic during follow up, independent of HIV infection (P≤0.04 for each line).Conclusion. HIV-1 infection decreases opsonising antibodies to VSA, and antibody to merozoite antigens. Opsonising antibodies were associated with lack of parasitemia during follow up, suggesting a role in protection.