High HLA-DP Expression and Graft-versus-Host Disease.

Publication Type:

Journal Article

Source:

The New England journal of medicine, Volume 373, Issue 7, p.599-609 (2015)

Keywords:

Adolescent, Adult, Female, Genetic Linkage, Genomics Core Facility, Genotype, Graft vs Host Disease, hematopoietic stem cell transplantation, Histocompatibility Testing, HLA-DP beta-Chains, Humans, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Proportional Hazards Models, Regulatory Sequences, Nucleic Acid, Unrelated Donors, Young Adult

Abstract:

Transplantation of hematopoietic cells from unrelated donors can cure blood disorders but carries a significant risk of acute graft-versus-host disease (GVHD). The risk is higher when the recipient and donor are HLA-DPB1-mismatched, but the mechanisms leading to GVHD are unknown. The HLA-DPB1 regulatory region variant rs9277534 is associated with HLA-DPB1 expression. We tested the hypothesis that the GVHD risk correlates with the rs9277534 allele linked to the mismatched HLA-DPB1 in the recipient.