High HLA-DP Expression and Graft-versus-Host Disease.

Publication Type:

Journal Article


The New England journal of medicine, Volume 373, Issue 7, p.599-609 (2015)


Adolescent, Adult, Female, Genetic Linkage, Genomics Core Facility, Genotype, Graft vs Host Disease, hematopoietic stem cell transplantation, Histocompatibility Testing, HLA-DP beta-Chains, Humans, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Proportional Hazards Models, Regulatory Sequences, Nucleic Acid, Unrelated Donors, Young Adult


Transplantation of hematopoietic cells from unrelated donors can cure blood disorders but carries a significant risk of acute graft-versus-host disease (GVHD). The risk is higher when the recipient and donor are HLA-DPB1-mismatched, but the mechanisms leading to GVHD are unknown. The HLA-DPB1 regulatory region variant rs9277534 is associated with HLA-DPB1 expression. We tested the hypothesis that the GVHD risk correlates with the rs9277534 allele linked to the mismatched HLA-DPB1 in the recipient.