High epidermal growth factor receptor expression in metastatic colorectal cancer lymph nodes may be more prognostic of poor survival than in primary tumor.

Publication Type:

Journal Article

Source:

American journal of clinical oncology, Volume 32, Issue 3, p.245-52 (2009)

Keywords:

2009, ADENOCARCINOMA, Adenocarcinoma, Mucinous, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Center-Authored Paper, Clinical Research Division, Colorectal Neoplasms, Female, Follow-Up Studies, Humans, Immunoenzyme Techniques, Lymphatic Metastasis, Male, Middle Aged, Prognosis, Public Health Sciences Division, Receptor, Epidermal Growth Factor, Research Trials Office Core Facility - Biostatistics Service, Shared Resources, Survival Rate, Tissue Array Analysis, Treatment Outcome, Young Adult

Abstract:

High epidermal growth factor receptor (EGFR) expression in the primary tumor predicts poor survival in colorectal cancer. However, EGFR expression may be discordant in primary tumor versus nodal or distant metastasis. We evaluated prognostic values of high EGFR expression in nodal metastasis versus primary tumor tissue.