Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis.

Publication Type:

Journal Article

Authors:

Donnell, Deborah; Baeten, Jared M; Kiarie, James; Thomas, Katherine K; Stevens, Wendy; Cohen, Craig R; McIntyre, James; Lingappa, Jairam R; Celum, Connie

Source:

Lancet, Volume 375, Issue 9731, p.2092-8 (2010)

Keywords:

2010, Adult, AIDS Serodiagnosis, Anti-Retroviral Agents, CD4 Lymphocyte Count, Cohort Studies, Female, Herpesvirus 2, Human, Heterosexuality, HIV Infections, HIV-1, Humans, Male, RNA, Viral, Sexual Partners, Training Support, Vaccine and Infectious Disease Division

Abstract:

High plasma HIV-1 RNA concentrations are associated with increased risk of HIV-1 transmission. Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners.