Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signaling.

Publication Type:

Journal Article

Source:

British journal of pharmacology (2014)

Keywords:

2014, August 2014, Clinical Research Division

Abstract:

Heteromerization of G protein-coupled receptors is key on the integration of extracellular signals and the subsequent cell response via several mechanisms including heteromer-selective ligand binding, trafficking and/or downstream signaling. Considering the modulatory impact of the lysophosphatidylinositol G protein-coupled receptor 55 (GPR55) on the function of cannabinoid receptor subtype 2 (CB2 R) in human neutrophils, a potential heteromerization of CB2 R and GPR55 was hypothesized.