Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model.

Publication Type:

Journal Article

Source:

The Prostate, Volume 70, Issue 6, p.591-600 (2010)

Keywords:

2010, ADENOCARCINOMA, Androgen-Binding Protein, Animals, Center-Authored Paper, Comparative Medicine Core Facility, Disease Models, Animal, DISEASE PROGRESSION, Flow Cytometry Core Facility, Human Biology Division, Male, MICE, Mice, Transgenic, Prostatic Neoplasms, Proto-Oncogene Proteins c-myc, Scientific Imaging Core Facility, Serine Endopeptidases, Shared Resources, Time Factors

Abstract:

Hepsin is a cell surface protease that is over-expressed in more than 90% of human prostate cancer cases. The previously developed Probasin-hepsin/Large Probasin-T antigen (PB-hepsin/LPB-Tag) bigenic mouse model of prostate cancer demonstrates that hepsin promotes primary tumors that are a mixture of adenocarcinoma and neuroendocrine (NE) lesions, and metastases that are NE in nature. However, since the majority of human prostate tumors are adenocarcinomas, the contribution of hepsin in the progression of adenocarcinoma requires further investigation.