Hemopoietic reserve in the older cancer patient: clinical and economic considerations.

Publication Type:

Journal Article

Source:

Cancer control : journal of the Moffitt Cancer Center, Volume 7, Issue 6, p.539-47 (2000)

Keywords:

Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Cost-Benefit Analysis, Dose-Response Relationship, Drug, Female, Hematopoietic System, Humans, Male, Neoplasms, NEUTROPENIA, Prognosis, Risk Assessment, Survival Analysis

Abstract:

Older individuals are at increased risk for myelosuppression, the most common complication of cytotoxic chemotherapy. Causes include reduction in hemopoietic stem cell reserve, increased prevalence of chronic diseases, and increased prevalence of anemia. Anemia is an independent risk factor for myelotoxicity, in part because it decreases the volume of distribution of anthracyclines, epipodophyllotoxins, and taxanes and increases the circulating concentration of free drugs.