Hematopoietic cell transplantation-comorbidity index and Karnofsky performance status are independent predictors of morbidity and mortality after allogeneic nonmyeloablative hematopoietic cell transplantation.

Publication Type:

Journal Article

Source:

Cancer, Volume 112, Issue 9, p.1992-2001 (2008)

Keywords:

2008, Adolescent, Adult, Aged, Center-Authored Paper, Child, Child, Preschool, Clinical Research Division, Comorbidity, Flow Cytometry Core Facility, Health Status, hematopoietic stem cell transplantation, Humans, Infant, Karnofsky Performance Status, Middle Aged, Research Trials Office Core Facility - Biostatistics Service, Shared Resources, Transplantation Conditioning, Transplantation, Homologous

Abstract:

Elderly and medically infirm cancer patients are increasingly offered allogeneic nonmyeloablative hematopoietic cell transplantation (HCT). A better understanding of the impact of health status on HCT outcomes is warranted. Herein, a recently developed HCT-specific comorbidity index (HCT-CI) was compared with a widely acceptable measure of health status, the Karnofsky performance status (KPS).