A (heat) shocking development: FBXW7 loss unleashes HSF1 to drive melanoma invasion and metastasis.

Publication Type:

Journal Article


Pigment cell & melanoma research (2015)


Melanoma is the deadliest form of skin cancer because of its strong tendency for local invasion, distant metastasis, and resistance to traditional cytotoxic chemotherapy. A more complete understanding of the genetic landscape of melanoma will define and clarify the molecular pathways that drive tumor growth and will also reveal new therapeutic targets. Indeed, this is already being borne out: multiple studies have demonstrated that activating mutations in components of the RAS/RAF/MEK/ERK pathway occur in over half of melanoma tumor samples and targeted inhibitors of this pathway are currently used to treat patients with these cancers. This article is protected by copyright. All rights reserved.