Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning.

Publication Type:

Journal Article


Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 23, Issue 9, p.1993-2003 (2005)


Adolescent, Adult, Aged, Child, Child, Preschool, Comorbidity, Female, Graft Rejection, Graft vs Tumor Effect, hematopoietic stem cell transplantation, Humans, Immunosuppressive Agents, LEUKEMIA, Male, Middle Aged, Probability, Transplantation Conditioning, Treatment Outcome, Vidarabine


We have used a nonmyeloablative conditioning regimen consisting of total-body irradiation (2 Gy) with or without fludarabine (30 mg/m(2)/d for 3 days) for related and unrelated hematopoietic cell transplantation (HCT) in patients with hematologic malignancies who were not candidates for conventional HCT because of age, medical comorbidities, or preceding high-dose HCT. This approach relied on graft-versus-tumor (GVT) effects for control of malignancy.