Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning.

Publication Type:

Journal Article

Source:

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 23, Issue 9, p.1993-2003 (2005)

Keywords:

Adolescent, Adult, Aged, Child, Child, Preschool, Comorbidity, Female, Graft Rejection, Graft vs Tumor Effect, hematopoietic stem cell transplantation, Humans, Immunosuppressive Agents, LEUKEMIA, Male, Middle Aged, Probability, Transplantation Conditioning, Treatment Outcome, Vidarabine

Abstract:

We have used a nonmyeloablative conditioning regimen consisting of total-body irradiation (2 Gy) with or without fludarabine (30 mg/m(2)/d for 3 days) for related and unrelated hematopoietic cell transplantation (HCT) in patients with hematologic malignancies who were not candidates for conventional HCT because of age, medical comorbidities, or preceding high-dose HCT. This approach relied on graft-versus-tumor (GVT) effects for control of malignancy.