Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.

Publication Type:

Journal Article

Source:

Diabetologia, Volume 53, Issue 11, p.2369-79 (2010)

Keywords:

2010, Animals, APOPTOSIS, Cell Proliferation, Cells, Cultured, Center-Authored Paper, Fatty Acids, Glucose, Immunohistochemistry, Insulin, Insulin-Secreting Cells, Male, Proinsulin, Public Health Sciences Division, Rats, Rats, Wistar, Reverse Transcriptase Polymerase Chain Reaction

Abstract:

Prolonged exposure of pancreatic beta cells to excessive levels of glucose and fatty acids, referred to as glucolipotoxicity, is postulated to contribute to impaired glucose homeostasis in patients with type 2 diabetes. However, the relative contribution of defective beta cell function vs diminished beta cell mass under glucolipotoxic conditions in vivo remains a subject of debate. We therefore sought to determine whether glucolipotoxicity in rats is due to impaired beta cell function and/or reduced beta cell mass, and whether older animals are more susceptible to glucolipotoxic condition.