Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study.

Publication Type:

Journal Article

Source:

Gastroenterology, Volume 136, Issue 4, p.1251-60 (2009)

Keywords:

2009, ADENOCARCINOMA, Adult, Aged, Aged, 80 and over, Australia, Canada, Case-Control Studies, Center-Authored Paper, Colorectal Neoplasms, DNA Glycosylases, Female, Genetic Predisposition to Disease, Genotype, Germ-Line Mutation, Heterozygote, Humans, Logistic Models, Male, Microsatellite Instability, Middle Aged, Public Health Sciences Division, Risk Factors, United States

Abstract:

The MutY human homologue (MYH) gene is a member of the base-excision repair pathway involved in the repair of oxidative DNA damage. The objective of this study was to determine colorectal cancer (CRC) risk associated with mutations in the MYH gene.