Germline Genetic Contributions to Risk for Esophageal Adenocarcinoma, Barrett's Esophagus, and Gastroesophageal Reflux.

Publication Type:

Journal Article


Journal of the National Cancer Institute, Volume 105, Issue 22, p.1711-8 (2013)


2013, Center-Authored Paper, Genomics Core Facility, Human Biology Division, November 2013, Public Health Sciences Division, Specimen Processing Core Facility


Esophageal adenocarcinoma (EA) is an increasingly common cancer with poor survival. Barrett's esophagus (BE) is the main precursor to EA, and every year 0.12% to 0.5% of BE patients progress to EA. BE typically arises on a background of chronic gastroesophageal reflux (GERD), one of the risk factors for EA.