Germline Genetic Contributions to Risk for Esophageal Adenocarcinoma, Barrett's Esophagus, and Gastroesophageal Reflux.

Publication Type:

Journal Article

Source:

Journal of the National Cancer Institute, Volume 105, Issue 22, p.1711-8 (2013)

Keywords:

2013, Center-Authored Paper, Genomics Core Facility, Human Biology Division, November 2013, Public Health Sciences Division, Specimen Processing Core Facility

Abstract:

Esophageal adenocarcinoma (EA) is an increasingly common cancer with poor survival. Barrett's esophagus (BE) is the main precursor to EA, and every year 0.12% to 0.5% of BE patients progress to EA. BE typically arises on a background of chronic gastroesophageal reflux (GERD), one of the risk factors for EA.