Genomic differences between estrogen receptor (ER)-positive and ER-negative human breast carcinoma identified by single nucleotide polymorphism array comparative genome hybridization analysis.

Publication Type:

Journal Article

Source:

Cancer, Volume 117, Issue 10, p.2024-34 (2011)

Keywords:

2011, Adult, Aged, Aged, 80 and over, Breast Neoplasms, Clinical Research Division, DNA Copy Number Variations, Female, Genetic Variation, GENOMIC INSTABILITY, Humans, loss of heterozygosity, Middle Aged, Neoplasms, Hormone-Dependent, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Public Health Sciences Division, Receptors, Estrogen

Abstract:

Estrogen receptor (ER) remains one of the most important biomarkers for breast cancer subtyping and prognosis, and comparative genome hybridization has greatly contributed to the understanding of global genetic imbalance. The authors used single-nucleotide polymorphism (SNP) arrays to compare overall copy number aberrations (CNAs) as well as loss of heterozygosity (LOH) of the entire human genome in ER-positive and ER-negative breast carcinomas.