Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.

Publication Type:

Journal Article

Source:

PloS one, Volume 6, Issue 12, p.e28632 (2011)

Keywords:

2011, Center-Authored Paper, Jan 12, January 2012, Shared Resources, Specimen Processing Core Facility, Vaccine and Infectious Disease Division

Abstract:

Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 serodiscordant heterosexual couples. To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use.