A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

Publication Type:

Journal Article

Source:

Nature genetics, Volume 41, Issue 11, p.1182-90 (2009)

Keywords:

2009, Blood Cell Count, Blood Cells, Center-Authored Paper, Chromosomes, Human, Pair 12, Coronary Artery Disease, Genetic Markers, Genome, Human, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Public Health Sciences Division, Selection, Genetic

Abstract:

The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.