Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses.

Publication Type:

Journal Article

Source:

The Prostate, Volume 70, Issue 7, p.735-44 (2010)

Keywords:

2010, Center-Authored Paper, Chromosome Mapping, Chromosomes, Human, Pair 22, Genetic Linkage, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Male, Pedigree, Prostatic Neoplasms, Public Health Sciences Division

Abstract:

Prostate cancer (PC) is generally believed to have a strong inherited component, but the search for susceptibility genes has been hindered by the effects of genetic heterogeneity. The recently developed sumLINK and sumLOD statistics are powerful tools for linkage analysis in the presence of heterogeneity.