Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.

Publication Type:

Journal Article

Authors:

Haiman, Christopher A; Chen, Gary K; Blot, William J; Strom, Sara S; Berndt, Sonja I; Kittles, Rick A; Rybicki, Benjamin A; Isaacs, William B; Ingles, Sue A; Stanford, Janet L; Diver, W Ryan; Witte, John S; Hsing, Ann W; Nemesure, Barbara; Rebbeck, Timothy R; Cooney, Kathleen A; Xu, Jianfeng; Kibel, Adam S; Hu, Jennifer J; John, Esther M; Gueye, Serigne M; Watya, Stephen; Signorello, Lisa B; Hayes, Richard B; Wang, Zhaoming; Yeboah, Edward; Tettey, Yao; Cai, Qiuyin; Kolb, Suzanne; Ostrander, Elaine A; Zeigler-Johnson, Charnita; Yamamura, Yuko; Neslund-Dudas, Christine; Haslag-Minoff, Jennifer; Wu, William; Thomas, Venetta; Allen, Glenn O; Murphy, Adam; Chang, Bao-Li; Zheng, S Lilly; Leske, M Cristina; Wu, Suh-Yuh; Ray, Anna M; Hennis, Anselm J M; Thun, Michael J; Carpten, John; Casey, Graham; Carter, Erin N; Duarte, Edder R; Xia, Lucy Y; Sheng, Xin; Wan, Peggy; Pooler, Loreall C; Cheng, Iona; Monroe, Kristine R; Schumacher, Fredrick; Le Marchand, Loic; Kolonel, Laurence N; Chanock, Stephen J; Vandenberg, David; Stram, Daniel O; Henderson, Brian E

Source:

Nature genetics, Volume 43, Issue 6, p.570-3 (2011)

Keywords:

2011, African Americans, Chromosomes, Human, Pair 17, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Public Health Sciences Division

Abstract:

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.