Publication Type:
Journal Article
Authors:
Vijai, Joseph;
Wang, Zhaoming;
Berndt, Sonja I;
Skibola, Christine F;
Slager, Susan L;
de Sanjose, Silvia;
Melbye, Mads;
Glimelius, Bengt;
Bracci, Paige M;
Conde, Lucia;
Birmann, Brenda M;
Wang, Sophia S;
Brooks-Wilson, Angela R;
Lan, Qing;
de Bakker, Paul I W;
Vermeulen, Roel C H;
Portlock, Carol;
Ansell, Stephen M;
Link, Brian K;
Riby, Jacques;
North, Kari E;
Gu, Jian;
Hjalgrim, Henrik;
Cozen, Wendy;
Becker, Nikolaus;
Teras, Lauren R;
Spinelli, John J;
Turner, Jenny;
Zhang, Yawei;
Purdue, Mark P;
Giles, Graham G;
Kelly, Rachel S;
Zeleniuch-Jacquotte, Anne;
Ennas, Maria Grazia;
Monnereau, Alain;
Bertrand, Kimberly A;
Albanes, Demetrius;
Lightfoot, Tracy;
Yeager, Meredith;
Chung, Charles C;
Burdett, Laurie;
Hutchinson, Amy;
Lawrence, Charles;
Montalvan, Rebecca;
Liang, Liming;
Huang, Jinyan;
Ma, Baoshan;
Villano, Danylo J;
Maria, Ann;
Corines, Marina;
Thomas, Tinu;
Novak, Anne J;
Dogan, Ahmet;
Liebow, Mark;
Thompson, Carrie A;
Witzig, Thomas E;
Habermann, Thomas M;
Weiner, George J;
Smith, Martyn T;
Holly, Elizabeth A;
Jackson, Rebecca D;
Tinker, Lesley F;
Ye, Yuanqing;
Adami, Hans-Olov;
Smedby, Karin E;
De Roos, Anneclaire J;
Hartge, Patricia;
Morton, Lindsay M;
Severson, Richard K;
Benavente, Yolanda;
Boffetta, Paolo;
Brennan, Paul;
Foretova, Lenka;
Maynadie, Marc;
McKay, James;
Staines, Anthony;
Diver, W Ryan;
Vajdic, Claire M;
Armstrong, Bruce K;
Kricker, Anne;
Zheng, Tongzhang;
Holford, Theodore R;
Severi, Gianluca;
Vineis, Paolo;
Ferri, Giovanni M;
Ricco, Rosalia;
Miligi, Lucia;
Clavel, Jacqueline;
Giovannucci, Edward;
Kraft, Peter;
Virtamo, Jarmo;
Smith, Alex;
Kane, Eleanor;
Roman, Eve;
Chiu, Brian C H;
Fraumeni, Joseph F;
Wu, Xifeng;
Cerhan, James R;
Offit, Kenneth;
Chanock, Stephen J;
Rothman, Nathaniel;
Nieters, AlexandraSource:
Nature communications, Volume 6, p.5751 (2015)
Keywords:
Collaborative Data Services Core Facility,
Specimen Processing Core Facility
Abstract:
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
