Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2.

Publication Type:

Journal Article

Authors:

Huang, Jie; Huffman, Jennifer E; Yamkauchi, Munekazu; Trompet, Stella; Asselbergs, Folkert W; Sabater-Lleal, Maria; Trégouët, David-Alexandre; Chen, Wei-Min; Smith, Nicholas L; Kleber, Marcus E; Shin, So-Youn; Becker, Diane M; Tang, Weihong; Dehghan, Abbas; Johnson, Andrew D; Truong, Vinh; Folkersen, Lasse; Yang, Qiong; Oudot-Mellkah, Tiphaine; Buckley, Brendan M; Moore, Jason H; Williams, Frances M K; Campbell, Harry; Silbernagel, Günther; Vitart, Veronique; Rudan, Igor; Tofler, Geoffrey H; Navis, Gerjan J; Destefano, Anita; Wright, Alan F; Chen, Ming-Huei; de Craen, Anton J M; Worrall, Bradford B; Rudnicka, Alicja R; Rumley, Ann; Bookman, Ebony B; Psaty, Bruce M; Chen, Fang; Keene, Keith L; Franco, Oscar H; Böhm, Bernhard O; Uitterlinden, Andre G; Carter, Angela M; Jukema, J Wouter; Sattar, Naveed; Bis, Joshua C; Ikram, Mohammad A; Sale, Michèle M; McKnight, Barbara; Fornage, Myriam; Ford, Ian; Taylor, Kent; Slagboom, P Eline; McArdle, Wendy L; Hsu, Fang-Chi; Franco-Cereceda, Anders; Goodall, Alison H; Yanek, Lisa R; Furie, Karen L; Cushman, Mary; Hofman, Albert; Witteman, Jacqueline C M; Folsom, Aaron R; Basu, Saonli; Matijevic, Nena; van Gilst, Wiek H; Wilson, James F; Westendorp, Rudi G J; Kathiresan, Sekar; Reilly, Muredach P; Tracy, Russell P; Polasek, Ozren; Winkelmann, Bernhard R; Grant, Peter J; Hillege, Hans L; Cambien, Francois; Stott, David J; Lowe, Gordon D; Spector, Timothy D; Meigs, James B; Marz, Winfried; Eriksson, Per; Becker, Lewis C; Morange, Pierre-Emmanuel; Soranzo, Nicole; Williams, Scott M; Hayward, Caroline; van der Harst, Pim; Hamsten, Anders; Lowenstein, Charles J; Strachan, David P; O'Donnell, Christopher J

Source:

Arteriosclerosis, thrombosis, and vascular biology (2014)

Keywords:

2014, March 2014, Public Health Sciences Division

Abstract:

Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for endogenous fibrinolysis. In some populations, elevated plasma levels of tPA have been associated with myocardial infarction and other cardiovascular diseases. We conducted a meta-analysis of genome-wide association studies to identify novel correlates of circulating levels of tPA.