Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos.

Publication Type:

Journal Article

Authors:

Pino-Yanes, Maria; Gignoux, Christopher R; Galanter, Joshua M; Levin, Albert M; Campbell, Catarina D; Eng, Celeste; Huntsman, Scott; Nishimura, Katherine K; Gourraud, Pierre-Antoine; Mohajeri, Kiana; O'Roak, Brian J; Hu, Donglei; Mathias, Rasika A; Nguyen, Elizabeth A; Roth, Lindsey A; Padhukasahasram, Badri; Moreno-Estrada, Andres; Sandoval, Karla; Winkler, Cheryl A; Lurmann, Fred; Davis, Adam; Farber, Harold J; Meade, Kelley; Avila, Pedro C; Serebrisky, Denise; Chapela, Rocio; Ford, Jean G; Lenoir, Michael A; Thyne, Shannon M; Brigino-Buenaventura, Emerita; Borrell, Luisa N; Rodriguez-Cintron, William; Sen, Saunak; Kumar, Rajesh; Rodriguez-Santana, Jose R; Bustamante, Carlos D; Martinez, Fernando D; Raby, Benjamin A; Weiss, Scott T; Nicolae, Dan L; Ober, Carole; Meyers, Deborah A; Bleecker, Eugene R; Mack, Steven J; Hernandez, Ryan D; Eichler, Evan E; Barnes, Kathleen C; Williams, L Keoki; Torgerson, Dara G; Burchard, Esteban G

Source:

The Journal of allergy and clinical immunology (2014)

Abstract:

IgE is a key mediator of allergic inflammation, and its levels are frequently increased in patients with allergic disorders.

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