Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 19, Issue 7, p.1822-30 (2010)

Keywords:

2010, Adult, Aged, Carbon-Nitrogen Ligases, Case-Control Studies, Dihydrouracil Dehydrogenase (NADP), DNA (Cytosine-5-)-Methyltransferase, Female, folic acid, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Methylenetetrahydrofolate Dehydrogenase (NADP), Middle Aged, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Public Health Sciences Division, Shared Resources, Specimen Processing Core Facility, thymidylate synthase, Tumor Markers, Biological

Abstract:

We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with risk of ovarian carcinoma overall and to use the large sample of assembled cases to investigate associations by histologic type.