Genetic variation in calcium-sensing receptor and risk for colon cancer.

Publication Type:

Journal Article


Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 17, Issue 10, p.2755-65 (2008)


2008, Adult, Aged, Case-Control Studies, Center-Authored Paper, Chi-Square Distribution, Colonic Neoplasms, diet, Female, Genetic Variation, Genotype, Haplotypes, Humans, Life Style, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Public Health Sciences Division, Receptors, Calcium-Sensing, RISK, Shared Resources, Specimen Processing Core Facility


Experimental and epidemiologic studies have suggested that high calcium intake is associated with decreased colon cancer risk, yet very limited data are available for candidate genes in the calcium-vitamin D pathway and colon cancer risk. To address this, we evaluated whether calcium-sensing receptor (CASR) single-nucleotide polymorphisms are associated with colon cancer risk. We also examined interactions among CASR, calcium, and vitamin D intake and previously genotyped vitamin D-related genes.