Genetic variation in calcium-sensing receptor and risk for colon cancer.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 17, Issue 10, p.2755-65 (2008)

Keywords:

2008, Adult, Aged, Case-Control Studies, Center-Authored Paper, Chi-Square Distribution, Colonic Neoplasms, diet, Female, Genetic Variation, Genotype, Haplotypes, Humans, Life Style, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Public Health Sciences Division, Receptors, Calcium-Sensing, RISK, Shared Resources, Specimen Processing Core Facility

Abstract:

Experimental and epidemiologic studies have suggested that high calcium intake is associated with decreased colon cancer risk, yet very limited data are available for candidate genes in the calcium-vitamin D pathway and colon cancer risk. To address this, we evaluated whether calcium-sensing receptor (CASR) single-nucleotide polymorphisms are associated with colon cancer risk. We also examined interactions among CASR, calcium, and vitamin D intake and previously genotyped vitamin D-related genes.