Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 19, Issue 1, p.89-100 (2010)

Keywords:

2010, Case-Control Studies, Center-Authored Paper, Colorectal Neoplasms, diet, Dietary Supplements, Epidemiology Core Facility, Female, folic acid, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2), Microsatellite Instability, Middle Aged, Polymorphism, Single Nucleotide, Public Health Sciences Division, Registries, Risk Factors, Shared Resources, Specimen Processing Core Facility, Tumor Markers, Biological

Abstract:

The MTHFR C677T TT genotype is associated with a 15% to 18% reduction in colorectal cancer risk, but it is not clear if other variants of the gene are associated with colorectal cancer risk.