Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc.

Publication Type:

Journal Article

Source:

PloS one, Volume 4, Issue 11, p.e7839 (2009)

Keywords:

2009, Alleles, Animals, Basic Sciences Division, Binding Sites, Center-Authored Paper, chromatin, Clinical Research Division, Collaborative Data Services Core Facility, Embryonic Stem Cells, Epigenesis, Genetic, Gene Expression Regulation, Histones, Immunoprecipitation, METHYLATION, MICE, Models, Biological, PHENOTYPE, Proto-Oncogene Proteins c-myc, Scientific Imaging Core Facility, Shared Resources

Abstract:

The Myc oncoprotein, a transcriptional regulator involved in the etiology of many different tumor types, has been demonstrated to play an important role in the functions of embryonic stem (ES) cells. Nonetheless, it is still unclear as to whether Myc has unique target and functions in ES cells.