A functional element necessary for fetal hemoglobin silencing.

Publication Type:

Journal Article

Source:

The New England journal of medicine, Volume 365, Issue 9, p.807-14 (2011)

Keywords:

2011, Adult, Basic Sciences Division, beta-Globins, beta-Thalassemia, Center-Authored Paper, Child, Chromatin Assembly and Disassembly, Clinical Research Division, Female, Fetal Hemoglobin, Gene Deletion, Gene Expression Regulation, Gene Silencing, Genomics Core Facility, Humans, Male, October 2011, Pedigree, PHENOTYPE, Shared Resources, Trans-Activators

Abstract:

An improved understanding of the regulation of the fetal hemoglobin genes holds promise for the development of targeted therapeutic approaches for fetal hemoglobin induction in the β-hemoglobinopathies. Although recent studies have uncovered trans-acting factors necessary for this regulation, limited insight has been gained into the cis-regulatory elements involved.