A formal risk-benefit framework for genomic tests: facilitating the appropriate translation of genomics into clinical practice.

Publication Type:

Journal Article


Genetics in medicine : official journal of the American College of Medical Genetics, Volume 12, Issue 11, p.686-93 (2010)


2010, Center-Authored Paper, Consortium Authored Paper, Decision Support Techniques, Evidence-Based Practice, Genetic Testing, GENOMICS, Humans, Pharmacogenetics, Public Health Sciences Division, Risk Assessment, Warfarin


Evaluation of genomic tests is often challenging because of the lack of direct evidence of clinical benefit compared with usual care and unclear evidence requirements. To address these issues, this study presents a risk-benefit framework for assessing the health-related utility of genomic tests.