Fish T cells: recent advances through genomics.

Publication Type:

Journal Article


Developmental and comparative immunology, Volume 35, Issue 12, p.1282-95 (2011)


2011, Adaptive Immunity, Animals, Antigens, CD, Cell Differentiation, Center-Authored Paper, Cytokines, Fishes, Gene Expression Profiling, Genetic Variation, GENOMICS, Immunity, Innate, Immunologic Memory, Mar 2012, March 2012, Receptors, Antigen, T-Cell, Recombinant Proteins, Signal Transduction, T-Lymphocyte Subsets, TRANSCRIPTION FACTORS, Vaccine and Infectious Disease Division


This brief review is intended to provide a concise overview of the current literature concerning T cells, advances in identifying distinct T cell functional subsets, and in distinguishing effector cells from memory cells. We compare and contrast a wealth of recent progress made in T cell immunology of teleost, elasmobranch, and agnathan fish, to knowledge derived from mammalian T cell studies. From genome studies, fish clearly have most components associated with T cell function and we can speculate on the presence of putative T cell subsets, and the ability to detect their differentiation to form memory cells. Some recombinant proteins for T cell associated cytokines and antibodies for T cell surface receptors have been generated that will facilitate studying the functional roles of teleost T cells during immune responses. Although there is still a long way to go, major advances have occurred in recent years for investigating T cell responses, thus phenotypic and functional characterization is on the near horizon.