Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma.

Publication Type:

Journal Article

Source:

The New England journal of medicine, Volume 367, Issue 15, p.1417-27 (2012)

Keywords:

Aged, Asbestos, Biological Markers, Case-Control Studies, Diagnosis, Differential, Extracellular Matrix Proteins, Female, Humans, Kaplan-Meier Estimate, Male, Mesothelioma, Middle Aged, Occupational Exposure, October 2012, Pleural Effusion, Pleural Effusion, Malignant, Pleural Neoplasms, Public Health Sciences Division, ROC Curve, Sensitivity and Specificity

Abstract:

New biomarkers are needed to detect pleural mesothelioma at an earlier stage and to individualize treatment strategies. We investigated whether fibulin-3 in plasma and pleural effusions could meet sensitivity and specificity criteria for a robust biomarker.