Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma.

Publication Type:

Journal Article


The New England journal of medicine, Volume 367, Issue 15, p.1417-27 (2012)


Aged, Asbestos, Biological Markers, Case-Control Studies, Diagnosis, Differential, Extracellular Matrix Proteins, Female, Humans, Kaplan-Meier Estimate, Male, Mesothelioma, Middle Aged, Occupational Exposure, October 2012, Pleural Effusion, Pleural Effusion, Malignant, Pleural Neoplasms, Public Health Sciences Division, ROC Curve, Sensitivity and Specificity


New biomarkers are needed to detect pleural mesothelioma at an earlier stage and to individualize treatment strategies. We investigated whether fibulin-3 in plasma and pleural effusions could meet sensitivity and specificity criteria for a robust biomarker.