Facioscapulohumeral muscular dystrophy: consequences of chromatin relaxation.

Publication Type:

Journal Article

Authors:

van der Maarel, Silvère M; Miller, Daniel G; Tawil, Rabi; Filippova, Galina N; Tapscott, Stephen J

Source:

Current opinion in neurology, Volume 25, Issue 5, p.614-20 (2012)

Keywords:

2012, Human Biology Division, September 2012

Abstract:

In recent years, we have seen remarkable progress in our understanding of the disease mechanism underlying facioscapulohumeral muscular dystrophy (FSHD). The purpose of this review is to provide a comprehensive overview of our current understanding of the disease mechanism and to discuss the observations supporting the possibility of a developmental defect in this disorder.